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Furthermore, the indole Main is substituted at R3 that has a carbonyl group which can be also bonded to some napthalene moeity. Napthalene is often a bicyclic structure of two fused benzene rings. This carbonyl bridge of JWH-018 classifies it for a ketone. JWH-018 is really an analog of THJ-018, by which the core indazole composition is substituted with the indole base. Pharmacology
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